Nicolsamide piritsi
Niclosamide ndeyemuromo bioavailable chlorinated salicylanilide, ine anthelmintic uye inogona antineoplastic chiitiko.Pamusoro pekutonga nemuromo, niclosamide inonyanya kukonzera kuderedzwa kweiyo androgen receptor (AR) musiyano V7 (AR-V7) kuburikidza neproteasome-mediated nzira.Izvi zvinodzikisira kutaura kweiyo AR musiyano, inhibits AR-V7-mediated transcriptal chiitiko, uye inoderedza AR-V7 kutora kune prostate-specific antigen (PSA) gene kusimudzira.Niclosamide zvakare inodzivirira AR-V7-mediated STAT3 phosphorylation uye activation.Izvi zvinodzivisa AR/STAT3-mediated kusaina uye inodzivirira kutaura kweSTAT3 yakananga majini.Pamwe chete, izvi zvinogona kutadzisa kukura kweARV-V7-overexpressing cancer maseru.Iyo AR-V7 mutsauko, iyo yakavharidzirwa neinobatika splicing yeAR exons 1/2/3/CE3, inokwidziridzwa mumhando dzakasiyana dzekenza masero, uye inobatanidzwa nekufambira mberi kwegomarara uye kuramba kurapwa kwakanangwa neAR.
Kuumbwa:
Imwe neimwe bolus cotnains 1250 mg niclosamide
Chiratidzo:
Kune vanochera vane utachiona paramphistomes, cestodiasis, semombe uye gwai's moniezia, avitellina centripunctata, nezvimwe.
Dosage uye Kushandisa:
Nemuromo imwe neimwe 1kg uremu hwemuviri.
Mombe: 40-60mg
Makwai: 60-70mg
Nguva yekubvisa:
Makwai: 28 mazuva.
Mombe: mazuva makumi maviri nemasere.
Package size: 5 piritsi pa blister, 10 blister pabhokisi
